[Frontiers in Bioscience 7, d1464-1474, June 1, 2002] 1464 THREE-DIMENSIONAL RECONSTRUCTION OF RYANODINE RECEPTORS

نویسندگان

  • Terence Wagenknecht
  • Montserrat Samsó
چکیده

1. Abstract 2. Introduction 3. Basic Features of RyR Architecture 3.1. Cytoplasmic Assembly/Region 3.2. Transmembrane assembly/region 4. Comparison of RyR Isoforms 5. Conformational States or RyR1 and RyR3 6. Interaction Sites of RyR Modulators 6.1. FKBP12 6.2. Calmodulin 6.3. Dihydropyridine Receptor 7. Correlation of RyR1’s amino acid sequence with its 3D architecture 8. Perspective 8.1. High resolution 8.2. 3D localization of functional/structural sites 9. Acknowledgment 10. References

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Regulation of mammalian ryanodine receptors.

Ryanodine receptors (RyRs) are large, high conductance Ca2+ channels that control the level of intracellular Ca2+ by releasing Ca2+ from an intracellular compartment, the sarco/endoplasmic reticulum. Mammalian tissues express 3 closely related ryanodine receptors (RyRs) known as skeletal muscle (RyR1), cardiac muscle (RyR2) and brain (RyR3). The RyRs are isolated as 30S protein complexes compri...

متن کامل

Redox sensing properties of the ryanodine receptor complex.

The release mechanism regulating SR Ca2+ homeostasis is significantly more sensitive than the uptake mechanisms. The exquisite sensitivity exhibited by ryanodine-sensitive Ca2+ channel complexes (i.e., ryanodine receptors, RyRs) to functional perturbation by chemically diverse sulfhydryl-modifying compounds can include phases of activation and inhibition that are dependent on the concentration ...

متن کامل

Calcium signaling between sarcolemmal calcium channels and ryanodine receptors in heart cells.

Cardiac excitation-Ca2+ release coupling is, in essence, a tale of two molecules, sarcolemmal voltage-gated L-type Ca2+ channels (LCCs) and intracellular ryanodine receptors (RyRs), communicating via the Ca2+-induced Ca2+ release mechanism. Recent advances have provided a microscopic view of the intermolecular Ca2+ signaling between LCCs and RyRs. In a dyadic junction or a "couplon", LCCs open ...

متن کامل

Mechanisms that turn-off intracellular calcium release channels.

Calcium release from intracellular stores is a common phenomenon in cells. Calcium release is mediated by two classes of Ca2+ release channels, the ryanodine receptors (RyRs) and the inositol trisphosphate receptors (IP3Rs). There are three types of RyR and three types of IP3Rs. Different cells have different complements of RyR and IP3Rs. In most cases, it is clear what turns-on these channels....

متن کامل

Ryanodine receptors in smooth muscle.

The sarcoplasmic reticulum (SR) of smooth muscle is endowed with two different types of Ca2+ release channels, i.e. inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs). In general, both release channels mobilize Ca2+ from the same internal store in smooth muscle. While the importance of IP3Rs in agonist-induced contraction is well established, the role of RyRs in excit...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2002